Towards personalized medicine

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Other publications

2014
  • Lipoprotein Metabolism Indicators Improve Cardiovascular Risk Prediction. Van Schalkwijk, van Schalkwijk DB, de Graaf AA, Tsivtsivadze E, Parnell LD, van der Werff-van der Vat BJ, van Ommen B, van der Greef J, Ordovás JM. PLoS One. 2014 Mar 25;9(3):e92840. doi: 10.1371/journal.pone.0092840. eCollection 2014.
  • Phenotypic flexibility as key factor in the human nutrition and health relationship and health relationship, 2014. Ben van Ommen, Jan van der Greef, Jose Maria Ordovas, Hannelore Daniel. Genes & nutrition 9 (5), 1-9 (2014)
  • Of Monkeys and Men: A Metabolomic Analysis of Static and Dynamic Urinary Metabolic Phenotypes in Two Species. Edoardo Saccenti1, Leonardo Tenori, Paul Verbruggen, Marieke E. Timmerman, Jildau Bouwman, Jan van der Greef, Claudio Luchinat, Age K. Smilde. PLOS ONE, September 2014 | Volume 9 | Issue 9 | e106077
  • Non-European traditional herbal medicines in Europe: A community herbal monograph perspective. Liping Qu, Wenjun Zou, Zhenxiang Zhou, Tingmo Zhang, Jan Van der Greef, Mei Wang, Journal of Ethnopharmacology 156( 2014) 107–114
  • The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a systems approach to resilience, robustness and control.Aschbacher K, Rodriguez-Fernandez M, van Wietmarschen H, Tomiyama AJ, Jain S, Epel E, Doyle FJ 3rd, van der Greef J. Interface Focus. 2014 Oct 6;4(5):20140020. doi: 10.1098/rsfs.2014.0020.
  • Network identification of hormonal regulation. Vis DJ, Westerhuis JA, Hoefsloot HC, Roelfsema F, van der Greef J, Hendriks MM, Smilde AK. PLoS One. 2014 May 22;9(5):e96284. doi: 10.1371/journal.pone.0096284. eCollection 2014.
  • Ultraweak photon emission as a non-invasive health assessment: a systematic review. Ives JA, van Wijk EP, Bat N, Crawford C, Walter A, Jonas WB, van Wijk R, van der Greef J. PLoS One. 2014 Feb 28;9(2):e87401. doi: 10.1371/journal.pone.0087401. eCollection 2014.
  • Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review. Van Wijk R, Van Wijk EP, van Wietmarschen HA, Greef Jv. J Photochem Photobiol B. 2014 Oct 5;139:39-46. doi: 10.1016/j.jphotobiol.2013.11.014. Epub 2013 Dec 2.
  • Correlated measurement error hampers association network inference. Kaduk M, Hoefsloot HC, Vis DJ, Reijmers T, van der Greef J, Smilde AK, Hendriks MM. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 1;966:93-9. doi: 10.1016/j.jchromb.2014.04.048. Epub 2014 May 2.
  • A Personalized Medicine Approach to Subtype Identification in Obesity: Are Circadian Leptin-Cortisol Interactions a Vulnerability Factor? Aschbacher, K.; Rodriguez-Fernandez, M.; Jain, S.; van Wietmarschen, H.; Doyle, F.; van der Greef, J. Psychosomatic Medicine, Volume 76, Number 3, pp. A18-A18 (2014)
  • Towards a Systems Model of Resilience from Concept Analysis to Quantitative Modeling. Jain, S.; Sprengel, M.; Teo, L.; Crawford, C.; Draper, R.; van Wietmarchen, H.; de Graaf, A.A.; van der Greef, J.; John, I; Jonas, W. Psychosomatic Medicine, Volume 76, Number 3, pp. A24-A24 (2014)
2013
  • Van Wijk R, Van Wijk EPA, Schroen Y, van der Greef J, Imaging human spontaneous photon emission: Historic development, recent data and perspectives, Trends in Photochemistry & Photobiology, Vol. 15, 27-40.
  • Van Wijk, Eduard P.A., Jan van der Greef, and Roeland van Wijk, Human photon dynamics determined by using photon count statistics, in New Developments in Photon and Material Research, J. Jang, Editor 2013, Nova Science Publishers: New York.
  • Van Wijk, Eduard P.A., Yu Yan, and Roeland van Wijk, Ultra-weak photon emission from organisms, in The Field of Cells, D. Fels and M. Cifra, Editors. (accepted 2013; in press), Basel University Press: Basel, Switzerland.
  • Van Wijk, Eduard P.A., John Ackerman, Roeland Van Wijk, Meditation – a link to spirituality and health. A novel approach to a human consciousness field experiment, in Meditation – Neuroscientific Approaches and Philosophical Implications, S. Schmidt and H. Walach, Editors, 2013, Springer: New York.
  • Greef J Van Der (2013) Looking back into the future: 30 years of metabolomics at TNO. Mass Spectrom Rev 1–17.
  • Herman van Wietmarschen, Mei Wang, Jan van der Greef. Personalized treatment effects of Rehmannia 6 on subjects with metabolic syndrome. Accepted by J of Ethnopharmacology.
2012
  • Wei H, Pasman W, Rubingh C, Wopereis S, Tienstra M, Schroen J, Wang M, Verheij E, van der Greef J. (2012) Urine metabolomics combined with the personalized diagnosis guided by Chinese Medicine reveals subtypes of pre-diabetes. Mol Biosyst 8(5): 1482-91. Impact factor: 4.015
  • Wietmarschen, H. Van, & Greef, J. Van Der. (2012). Metabolite Space of Rheumatoid Arthritis. British Journal of Medicine and medical research, 2(3), 469–483.
  • Van Wijk EPA, Groeneveld M, Van der Greef J, Van Wijk R (2011). Unusual optical properties of collagen and implications for the primo-vascular system. In: The Primo Vascular System: It’s Role in Cancer and Regeneration. Soh KS, Kang KA, David K (Eds.) Springer: New York pp235-241
  • Van Wijk, E., J. van der Greef, and R. van Wijk, Human photon dynamics determined by using photon count statistics, in New Developments in Photon and Material Research, J. Jang, Editor 2012, Nova Science Publishers: New York.
  • Van Wijk, E., Y. Yan, and E. van Wijk, Ultra-weak photon emission from organisms, in The Field of Cells, D. Fels and M. Cifra, Editors. (accepted 2012), Basel University Press: Basel, Switzerland.
2011
  • Van der Greef, Jan, 2011. All systems go. Article in Nature, Perspective, Volume 480, p. 87
  • Van Wietmarschen, Reijmers, Van der Kooij, Schroën, Wei, Hankemeier, Meulman, Van der Greef, 2011. Sub-Typing of Rheumatic Diseases Based on a Systems Diagnosis Questionnaire. Plos ONE, September 2011, volume 6, Issue 9, E24846.
2010
  • Jing Zhou, Zhiliang Xu, Hongwei Kong, Xin Lu, Guowang Xu, 2010. Comparison of phenolic components among different species of Dendrobium (Shihu Fengdou) and determination of their active components—moscatilin and gigantol, Chinese Journal of Chromatography, 28, 566-571.
  • Nan Wang, Yi Zhang, Xiang Li, Yingpeng Tong, Kong Hongwei, Guowang Xu, 2010. Analysis of volatile oils of Ligusticum chuanxiong Hort. from different geographical origins by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry, Chinese Journal of Chromatography , 28 (4), 329-335.
  • Van der Greef Jan; van Wietmarschen Herman; Schroen Jan; Wang Mei; Hankemeier Thomas; Xu Guowang, Systems Biology-Based Diagnostic Principles as Pillars of the Bridge between Chinese and Western Medicine. Planta Medica 2010;76:1-12.
  • Van Wijk Eduard P A; Van Wijk Roeland; Bajpai Rajendra P; Van der Greef Jan, Statistical analysis of the spontaneously emitted photon signals from palm and dorsal sides of both hands in human subjects. Journal of photochemistry and photobiology. B, Biology 2010;99(3):133-43.
  • Van Wijk Eduard P A; Van Wijk Roeland; Bosman Saskia, Using ultra-weak photon emission to determine the effect of oligomeric proanthocyanidins on oxidative stress of human skin. Journal of photochemistry and photobiology. B, Biology 2010;98(3):199-206.
  • Van Wijk Roeland; Van der Greef Jan; Van Wijk Eduard P A, Human ultraweak photon emission in relation to the Yin Yang concept of Chinese Medicine. J Acupunct Meridian Stud 2010;3(4):221−231
  • Yan Gu, Yifei Zhang, Xianzhe Shi, Xiaoying Li, Jie Hong, Jing Chen, Weiqiong Gu, Xin Lu, Guowang Xu*, Guang Ning* (2010) Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta, 81: 766–772
2009
  • Hu Chunxiu; van der Heijden Rob; Wang Mei; van der Greef Jan; Hankemeier Thomas; Xu Guowang, Analytical strategies in lipidomics and applications in disease biomarker discovery. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2836-46.
  • Wang Jiangshan; van der Heijden Rob; Spruit Shannon; Hankermeier Thomas; Chan Kelvin; van der Greef Jan; Xu Guowang; Wang Mei, Quality and safety of Chinese herbal medicines guided by a systems biology perspective.Journal of ethnopharmacology 2009;126(1):31-41.
  • Xiang Li, Zhiliang Xu, Xin Lu, Xuehui Yang, Peiyuan Yin, Hongwei Kong, Ying Yu, Guowang Xu* (2009) Comprehensive two-dimensional gas chromatography/ time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus, Anal. Chim. Acta, 633: 257–262
  • van Wietmarschen Herman; Yuan Kailong; Lu Cheng; Gao Peng; Wang Jiangshan; Xiao Cheng; Yan Xiaoping; Wang Mei; Schroën Jan; Lu Aiping; Xu Guowang; van der Greef Jan, Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients. Journal of clinical rheumatology: practical reports on rheumatic & musculoskeletal diseases 2009;15(7):330-7.
  • Wang Jiangshan; van der Heijden Rob; Spijksma Gerwin; Reijmers Theo; Wang Mei; Xu Guowang; Hankemeier Thomas; van der Greef Jan, Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry. Journal of chromatography. A 2009;1216(11):2169-78.
  • Kong Hongwei; Wang Mei; Venema Koen; Maathuis Annet; van der Heijden Rob; van der Greef Jan; Xu Guowang; Hankemeier Thomas, Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. Journal of chromatography. A 2009;1216(11):2195-203.
  • Jiangshan Wang, Theo Reijmers,Lijuan Chen, Rob van der Heijden,Mei Wang , Shuangqing Peng*, Thomas Hankemeier*, Guowang Xu *, Jan van der Greef (2009) Systems Toxicology Study of Doxorubicin on Rat Using Ultra High Performance Liquid Chromatography Coupled with Mass Spectrometry Based Metabolomics, Metabolomics, 5:407–418
  • Jiangshan Wang; Xinjie Zhao; Peiyuan Yin; Hongwei Kong; Guowang Xu (2009) Metabonomics Study on the Subtypes of Rheumatoid Arthritis, World Science and Technology (Modernization of Traditional Chinese Medicine and Materia Medica,11,201-205
2008
  • Yaqiong Qiu, Xin Lu, Tao Pang, Chengfei Ma, Xiang Li, Guowang Xu*(2008) Determination of Radix Ginseng volatile oils at different ages by Comprehensive two-dimensional gas chromatography / time-of-flight mass spectrometry, J. Sep. Sci., 31(19):3451-3457.
  • Xinjie Zhao, Yi Zhang, Peiyuan Yin, Chong Deng, Jing Chen, Zhang Wang, Guowang Xu (2008) Effect of a Traditional Chinese Medicine Preparation Xindi Soft Capsule on Rat Model of Acute Blood Stasis: a Metabonomics Study Based on Liquid Chromatography-Mass Spectrometry, J. Chromatogr. B, 873(2), 151-158
  • Nadezhda Angelova, Hong-Wei Kong, Rob Van Der Heijden, Shih-Ying Yang, Young Hae Choi, Hye Kyong Kim, Mei Wang, Thomas Hankemeier, Jan Van Der Greef, Guowang Xu And Rob Verpoorte, 2008. Recent methodology in the phytochemical analysis of ginseng?Phytochem. Anal. 19: 2–16
News

Light in Shaping Life. Biophotons in Biology and Medicine

The production of biological light (ultra-weak photon emission or biophotons) within many types of cells and tissues is characteristic of a living organism. You will begin a journey of discovery about biophotons in relationshipto biological matter and about how such biophotons can be detected utilizing specialized very photon-sensitivetechnologies.

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Pill to Person, an interview with Dr. Herman van Wietmarschen

“A single pill to cure every rheumatoid arthritis patient is a dated idea,” explains Herman van Wietmarschen. “People react differently to drugs because their genetic make-up and their life habits aren’t the same. It’s time to figure out to which subgroup patients belong, to get every patient the best drug as soon as possible.”

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Tradition Meets Science, an interview with Dr. Koko Wei

Koko Wei is validating Traditional Chinese medicine diagnoses with metabolomics analyses. “There may be value in the combination of both paths.” She has recently finished her PhD research at the Sino-Dutch Centre for Preventive and Personalized Medicine.

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